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Seattle loses 6-5 after blowing a 5-1 lead, as the Mariners see their six-game winning streak come to an end

RUFSeattle let one slip away Tuesday at San Francisco.

The Mariners blew a big lead and the Giants rallied to win 6-5, as pinch-hitter Darin Ruf hit a tiebreaking solo homer in the seventh inning at Oracle Park. It ended Seattle's six-game winning streak.

The second game of the two-game interleague set will be 6:45 p.m. Wednesday. Nick Margevicius pitches for Seattle opposite Tyler Anderson (an ex-Oregon Ducks player).

J.P. Crawford hit a bases-clearing double in the second inning and the Mariners (19-23) led 5-1 after Jose Marmolejos' RBI single in the third inning.

But, the Giants rallied, thanks to a solo homer by Alex Dickerson and a two-run shot by Mauricio Dubon.

Then, Ruf went deep off reliever Anthony Misiewicz in the seventh inning.

Donovan Solano had three hits and two runs scored for San Francisco (22-21).

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